Cracking the genetic code

Cracking the genetic code will enable the development of new, and more effective, personalized prevention and treatment efforts that will target underlying biology.

Study researchers will analyze DNA from saliva samples to point toward specific genes associated with eating disorders.

Before analysis can begin, DNA will be extracted from the saliva sample and genotyped to provide a read out of each participant’s genetic code.

The analysis process, known as a “genome-wide association study” (GWAS), involves comparing the genotypes of people with experience of an eating disorder, to the genotypes of those who have not experienced an eating disorder.

Looking for patterns

The research study will allow the researchers to identify genetic factors that determine why some people experience eating disorders, while others do not, and why some people living with eating disorders respond to certain treatments, while others do not.

Many international research studies to date have explored an individual’s genetic predisposition to eating disorders. However, only a handful of the specific predisposing genes have been identified, and there are many more to be found.

Comparing the EDGI samples with samples from individuals with other disorders will also help the researchers to understand the genetic relationship among eating disorders and commonly co-occurring conditions, such as depression, anxiety disorders, substance use problems, as well as other medical illnesses including metabolic conditions.